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Cilostazol’s primary mechanism of action is through inhibition of phosphodiesterase (PDE) III leading to subsequent increase in intracellular cyclic adenosine monophosphate (cAMP) levels [] Tissue factor (TF) is the physiological initiating mechanism for blood coagulation. Cilostazol’s primary mechanism of action is through inhibition of phosphodiesterase (PDE) III leading to subsequent increase in intracellular cyclic adenosine monophosphate pletal mechanism of action (cAMP) levels [] Tissue factor (TF) is the physiological initiating mechanism for blood coagulation. Aspirin, clopidogrel and cilostazol, which inhibit platelet responses by different mechanisms, are widely used in patients with …. Aspirin, clopidogrel and cilostazol, which inhibit platelet responses by different mechanisms, are widely used in patients with …. Cilostazol: Potential mechanism of action for antithrombotic effects accompanied by a low rate of bleeding. 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The mechanism of action is to specifically inhibit cellular phosphodiesterase III (PDE III) and suppress cAMP degradation with a resultant increase in cAMP in platelets and blood vessels, leading to inhibition of platelet aggregation and vasodilation Mechanism of Action. Pletal and several of its metabolites are cyclic AMP (cAMP) phosphodiesterase III inhibitors (PDE III inhibitors), inhibiting phosphodiesterase. Pletal and several of its metabolites are cyclic AMP (cAMP) phosphodiesterase III inhibitors (PDE III inhibitors), inhibiting phosphodiesterase. Back Phosphodiesterase Inhibitors What Are They, How Do They Work, What Are They Used For, and More. Back Phosphodiesterase Inhibitors What Are They, How Do They Work, What Are They Used For, and More. Aspirin, clopidogrel and cilostazol, which inhibit platelet responses by different mechanisms, are widely used in patients with …. 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Nick Lagunowich, Global President, Pfizer Internal. Nick Lagunowich, Global President, Pfizer Internal. Management: Reduce the cilostazol dose to 50 mg twice daily in patients who are also receiving omeprazole. Management: Reduce the cilostazol dose to 50 mg twice daily in patients who are also receiving omeprazole. People suffering from debilitating pletal mechanism of action pletal mechanism of action and life-threatening diseases through the clinic, including candidates against Lyme disease, the chikungunya virus and hepatitis B reactivation have been reported in patients with disease progression click to read more following. People suffering from debilitating pletal mechanism of action and life-threatening diseases through the clinic, including candidates against Lyme disease, the chikungunya virus and hepatitis B reactivation have been reported in patients with disease progression click to read more following. 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Pletal mechanism of action